Cytoprotective coating of mammalian cells with inorganic materials has been intensively studied with aims of functionalization and bioapplication of the cells. It is more difficult to coat mammalian cells with abiotic materials than biogenic ones because of incompatibility of abiotic ones as well as the fragility of mammalian cells. In this work, it was demonstrated that HeLa cells were coated with abiotic inorganic materials, titanium dioxide, by rigorously optimizing layer‐by‐layer process that ensures cytocompatibility. As a result, the adherent nature of the cells changed to the floating because of mechanical robustness of the coating. In addition, titanium dioxide coat protected the cells from UV‐C irradiation, which implied that the photo‐screening function of titanium dioxide was implanted to mammalian cells.

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二氧化钛对HeLa细胞的细胞保护涂层

哺乳动物细胞用无机材料的细胞保护性涂层已被深入研究，目的是使细胞功能化和生物应用。由于非生物材料的不相容性以及哺乳动物细胞的脆弱性，用非生物材料包被哺乳动物细胞比使用生物材料更困难。在这项工作中，通过严格优化确保细胞相容性的逐层过程，证明了HeLa细胞被非生物无机材料二氧化钛包裹。结果，由于涂层的机械坚固性，单元的粘附性质变为浮动的。此外，二氧化钛涂层保护细胞免受UV-C辐射，这意味着二氧化钛的光屏蔽功能已植入哺乳动物细胞。