Nuclear receptor coactivator 6 promotes HTR‐8/SVneo cell invasion and migration by activating NF‐κB‐mediated MMP9 transcription,Cell Proliferation

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Nuclear receptor coactivator 6 promotes HTR‐8/SVneo cell invasion and migration by activating NF‐κB‐mediated MMP9 transcription
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-08-13 , DOI: 10.1111/cpr.12876
Liang Wu _{1,

2,

3} , Kun‐qing Zhao ₄ , Wei Wang ₅ , Li‐na Cui ₄ , Lin‐li Hu _{1,

2,

3} , Xiang‐xiang Jiang ₄ , Jun Shuai _{1,

2,

3} , Ying‐pu Sun _{1,

2,

3}

Affiliation

NCOA6 is a transcription coactivator; its deletion in mice results in growth retardation and lethality between 8.5 and 12.5 dpc with defects in the placenta. However, the transcription factor(s) and the mechanism(s) involved in the function of NCOA6 in placentation have not been elucidated. Here, the roles of NCOA6 in human cytotrophoblast invasion and migration were studied.

中文翻译：

核受体共激活因子 6 通过激活 NF-κB 介导的 MMP9 转录促进 HTR-8/SVneo 细胞侵袭和迁移

NCOA6 是一种转录共激活因子；它在小鼠中的缺失导致 8.5 到 12.5 dpc 之间的生长迟缓和致死率，胎盘有缺陷。然而，转录因子和NCOA6在胎盘中的功能所涉及的机制尚未阐明。在这里，研究了 NCOA6 在人类细胞滋养层侵袭和迁移中的作用。

更新日期：2020-08-13

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