Decreased smooth muscle function, peristaltic activity, and gastrointestinal transit in dystrophic (mdx) mice,Neurogastroenterology & Motility

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Decreased smooth muscle function, peristaltic activity, and gastrointestinal transit in dystrophic (mdx) mice
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-08-12 , DOI: 10.1111/nmo.13968
Kulpreet Singh ₁ , Gurpreet Randhwa ₁ , Fadi N. Salloum ₁ , John R. Grider ₁ , Karnam S. Murthy ₁

Affiliation

Duchenne muscular dystrophy (DMD) is characterized by the lack of dystrophin in skeletal, cardiac, and smooth muscle. Slow colonic transit and constipation are common in DMD patients and animal models of DMD. However, the cause of this hypocontractility and the expression of contractile proteins in smooth muscle are unknown. The aim of the study was to investigate the expression of contractile proteins in the colonic smooth muscle and the function of the colon in control and mdx mice.

中文翻译：

营养不良（mdx）小鼠的平滑肌功能降低，蠕动和胃肠道运输减少

杜氏肌营养不良症（DMD）的特征在于骨骼肌，心脏和平滑肌中缺乏肌营养不良蛋白。缓慢的结肠运输和便秘在DMD患者和DMD动物模型中很常见。然而，这种低收缩性的原因和平滑肌中收缩蛋白的表达尚不清楚。该研究的目的是研究结肠平滑肌中收缩蛋白的表达以及对照组和mdx小鼠结肠的功能。

更新日期：2020-08-12

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