Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population.,Molecular Genetics & Genomic Medicine

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Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population.
Molecular Genetics & Genomic Medicine ( IF 1.5 ) Pub Date : 2020-08-13 , DOI: 10.1002/mgg3.1450
Xuling Chang _{1,

2} , Rajkumar Dorajoo ₃ , Yi Han ₄ , Ling Wang ₃ , Jianjun Liu _{3,

5} , Chiea-Chuen Khor _{3,

6} , Adrian F Low _{5,

7} , Mark Yan-Yee Chan ₅ , Jian-Min Yuan _{8,

9} , Woon-Puay Koh _{10,

11} , Yechiel Friedlander ₁₂ , Chew-Kiat Heng _{1,

2}

Affiliation

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Departments of Preventive Medicine and Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
National University Heart Centre, National University Health System, Singapore, Singapore.
Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Health Systems and Services Research, Duke-NUS Medical School Singapore, Singapore, Singapore.
School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Haptoglobin (Hp) is a plasma protein with strong anti‐inflammation and antioxidant activities. Its plasma level is known to be inversely associated with many inflammatory diseases, including cardiovascular diseases. However, the association of HP genetic variants with coronary artery disease (CAD) severity/mortality, and how they interact with common CAD risk factors are largely unknown.

中文翻译：

触珠蛋白遗传变异与冠状动脉疾病 (CAD) 危险因素之间的相互作用对新加坡华人人群 CAD 严重程度的影响。

触珠蛋白（Hp）是一种血浆蛋白，具有很强的抗炎和抗氧化活性。已知其血浆水平与许多炎症疾病（包括心血管疾病）呈负相关。然而， HP基因变异与冠状动脉疾病 (CAD) 严重程度/死亡率的关联，以及它们如何与常见 CAD 危险因素相互作用，目前尚不清楚。

更新日期：2020-10-12

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