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Planning dosimetry for 90 Y radioembolization with glass microspheres: Evaluating the fidelity of 99m Tc-MAA and partition model predictions.
Medical Physics ( IF 3.2 ) Pub Date : 2020-08-13 , DOI: 10.1002/mp.14452
M Allan Thomas 1 , Armeen Mahvash 2 , Mohamed Abdelsalam 2 , Ahmed O Kaseb 3 , S Cheenu Kappadath 1
Affiliation  

99mTc‐MAA‐SPECT/CT may be used in 90Y‐glass microsphere radioembolization treatment planning to assess perfused liver volumes and absorbed dose distributions. The partition model (PM) offers a more detailed planning dosimetry option beyond the single‐compartment model more traditionally used in 90Y radioembolization. As 90Y radioembolization treatments shift toward activities and doses that aim to achieve tumor control, accurate and reliable treatment planning dosimetry for both tumors and normal liver (NL) becomes more critical. In this work, we explore the accuracy and precision of 90Y dosimetry predictions from pretherapy 99mTc‐MAA and PM.

中文翻译:

使用玻璃微球体进行90 Y放射栓塞的计划剂量测定:评估99m Tc-MAA的保真度和分区模型预测。

99m Tc-MAA-SPECT / CT可用于90 Y玻璃微球体放射栓塞治疗计划,以评估灌注肝脏的体积和吸收的剂量分布。分区模型(PM)提供了比90 Y放射栓塞中传统上使用的单室模型更详细的计划剂量选择。随着90 Y放射栓塞治疗朝着旨在实现肿瘤控制的活动和剂量方向发展,针对肿瘤和正常肝脏(NL)的准确而可靠的治疗计划剂量测定变得越来越重要。在这项工作中,我们探索了治疗前99m Tc-MAA和PM进行的90 Y剂量学预测的准确性和精确性。
更新日期:2020-08-13
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