Effect of a dietary supplement composed of hydrolyzed milk proteins and vanillin on the reduction of infection and oxidative stress induced by chemotherapy.,Journal of Food Biochemistry

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Effect of a dietary supplement composed of hydrolyzed milk proteins and vanillin on the reduction of infection and oxidative stress induced by chemotherapy.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-14 , DOI: 10.1111/jfbc.13434
Mehdi Amouheydari ₁ , Mohammad Reza Ehsani ₁ , Iraj Javadi ₂

Affiliation

This study evaluates the antioxidant and antibacterial activity of a mixture of lactoferrin hydrolysate (LfH), whey protein hydrolysate (WPH) and vanillin in vitro and in vivo to design a chemoprotective supplement for reducing the infection and oxidative stress induced by chemotherapy. The designed supplement showed significant antibacterial activity against E. coli. The supplement with the highest concentration exhibited considerable antioxidant activity in (2,2‐diphenyl‐1‐picrylhydrazyl) DPPH free radicals, (2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) ABTS, and reducing power assays. In the biochemical analysis of liver homogenate, the supplement 3 increased the level of enzymes Catalase (CAT), Glutathione peroxidase (GPx), Superoxide dismutase (SOD), and also the Ferric Reducing Ability of Plasma (FRAP) while decreased thiobarbituric acid reactive substances (TBARS) in comparison to paclitaxel group, indicative of activity against oxidative stress. Antibacterial and antioxidant activity of the designed supplement makes it a good candidate for use as a functional food to reduce the side effects of chemotherapy.

中文翻译：

由水解乳蛋白和香草醛组成的膳食补充剂对减少化疗引起的感染和氧化应激的作用。

本研究评估了乳铁蛋白水解物 (LfH)、乳清蛋白水解物 (WPH) 和香草醛混合物的体外和体内抗氧化和抗菌活性，以设计一种化学保护补充剂，用于减少化疗引起的感染和氧化应激。设计的补充剂对大肠杆菌表现出显着的抗菌活性。最高浓度的补充剂对 (2,2-二苯基-1-三硝基苯肼基) DPPH 自由基、(2,2'-偶氮基-双 (3-乙基苯并噻唑啉-6-磺酸) ABTS 表现出相当大的抗氧化活性，并具有降低能力在肝脏匀浆的生化分析中，补充剂 3 增加了过氧化氢酶 (CAT)、谷胱甘肽过氧化物酶 (GPx)、超氧化物歧化酶 (SOD) 以及血浆铁还原能力 (FRAP) 的水平，同时降低了硫代巴比妥酸。与紫杉醇组相比，活性物质（TBARS）的含量表明所设计的补充剂具有抗氧化应激活性，使其成为减少化疗副作用的功能性食品的良好候选者。

更新日期：2020-10-11

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