Amygdalin is a cyanogenic glycoside, mainly present in the seeds of the Rosaceae family such as apricots, peaches, and bitter almond. In this study, in vitro genotoxic and antigenotoxic effects of amygdalin have been investigated on human peripheral blood lymphocytes using the comet assay. The antigenotoxic effect of amygdalin was performed against hydrogen peroxide (H₂O₂) using three different treatment types (pre‐, simultaneous, and post‐treatment). The isolated lymphocytes were incubated with different concentrations of amygdalin (0.86–13.75 µg/ml) alone and in combination with H₂O₂ (100 µM). The results indicated that amygdalin exhibited an antigenotoxic effect against H₂O₂, but it did not induce the genotoxic effect alone in tested concentrations in vitro on human lymphocytes.

中文翻译：

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通过彗星试验，苦杏仁苷对分离的人淋巴细胞的遗传毒性和抗原毒性潜力。

苦杏仁苷是一种氰化物苷，主要存在于蔷薇科的种子中，例如杏子，桃子和苦杏仁。在这项研究中，使用彗星试验研究了苦杏仁苷对人外周血淋巴细胞的体外遗传毒性和抗原毒性作用。苦杏仁苷对过氧化氢（H ₂ O ₂）的抗原毒性作用使用三种不同的治疗类型（预处理，同时和后处理）进行。分离的淋巴细胞分别与不同浓度的苦杏仁苷（0.86-13.75 µg / ml）以及与H ₂ O ₂（100 µM）一起孵育。结果表明苦杏仁苷对H ₂ O表现出抗原毒性作用。参见图₂，但是在体外测试浓度下，它不能单独诱导对人淋巴细胞的遗传毒性作用。