Bioorthogonal reactions including the bioorthogonal ligations and cleavages have become an active field of research in chemical biology, and they play important roles in chemical modification and functional regulation of biomolecules. This review summarizes the developments and applications of the representative bioorthogonal reactions including the Staudinger reactions, the metal‐mediated bioorthogonal reactions, the strain‐promoted cycloadditions, the inverse electron demand Diels‐Alder reactions, the light‐triggered bioorthogonal reactions, and the reactions of chloroquinoxalines and ortho‐dithiophenols.

中文翻译：

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化学生物学中的生物正交连接和切割。

包括生物正交连接和裂解在内的生物正交反应已成为化学生物学的一个活跃的研究领域，在生物分子的化学修饰和功能调控中发挥着重要作用。本文综述了代表性生物正交反应的发展和应用，包括施陶丁格反应、金属介导的生物正交反应、应变促进的环加成反应、逆电子需求Diels-Alder反应、光触发生物正交反应以及氯喹喔啉和邻二硫酚。