Front Cover: Effect of Regiochemistry and Methylation on the Anticancer Activity of a Ferrocene‐Containing Organometallic Nucleoside Analogue (ChemBioChem 17/2020),ChemBioChem

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Front Cover: Effect of Regiochemistry and Methylation on the Anticancer Activity of a Ferrocene‐Containing Organometallic Nucleoside Analogue (ChemBioChem 17/2020)
ChemBioChem ( IF 2.6 ) Pub Date : 2020-08-13 , DOI: 10.1002/cbic.202000547
Media K. Ismail ₁ , Zahra Khan ₂ , Marium Rana ₁ , Sarah L. Horswell ₁ , Louise Male ₁ , Huy V. Nguyen ₁ , Alessio Perotti ₂ , Isolda Romero‐Canelón ₃ , Edward A. Wilkinson ₁ , Nikolas J. Hodges ₂ , James H. R. Tucker ₁

Affiliation

Iron works: A ferrocene derivative, one of a series of ferronucleosides designed by the Tucker group, shows micromolar toxicity in a range of cancer cell lines. Their latest research shows the importance to activity of having arms in adjacent positions, with the 1,1’‐regioisomer much less active in bone cancer cell lines. On the other hand, N‐ or O‐methylation has much less of an effect; this rules out a conventional mechanism of action for a nucleoside, giving further weight to one that involves the iron centre. More information can be found in the full paper by N. J. Hodges, J. H. R. Tucker et al.

中文翻译：

封面：区域化学和甲基化对含二茂铁的有机金属核苷类似物的抗癌活性的影响（ChemBioChem 17/2020）

铁制品：二茂铁衍生物，是塔克（Tucker）研究小组设计的一系列铁核苷中的一种，在一系列癌细胞系中显示出微摩尔毒性。他们的最新研究表明，将臂置于相邻位置对于活性至关重要，而1,1'-区域异构体在骨癌细胞系中的活性要低得多。另一方面，N-或O-甲基化的影响要小得多。这排除了核苷的常规作用机理，进一步赋予了涉及铁中心的作用。可以在N. J. Hodges，J. H. R. Tucker等人的全文中找到更多信息。

更新日期：2020-09-01

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