In this case report, we describe the results of next generation non‐targeted cerebrospinal spinal fluid (CSF) metabolomics in a patient presenting with a prolonged delirium and elevated serum ammonia after standard electroconvulsive therapy treatment. These studies subsequently, in part, revealed abnormalities in the citric acid cycle, a finding previously reported in the bipolar literature. The patient subsequently has had a sustained response to pioglitazone, a mitochondrially targeted agent, in contrast to established medical and interventional therapies.

中文翻译：

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脑脊液代谢组学可唯一确定提示双相情感障碍电惊厥治疗期间麻醉反应风险的途径。

在本病例报告中，我们描述了在标准电惊厥治疗后出现long妄延长和血清氨升高的患者中，下一代非目标性脑脊髓液（CSF）代谢组学的结果。这些研究随后部分地揭示了柠檬酸循环中的异常，这一发现先前在双极性文献中已有报道。与既定的医学和介入疗法相比，患者随后对吡格列酮（一种线粒体靶向药物）产生了持续反应。