Recent Advances in the Synthesis of Tamoxifen and Analogues in Medicinal Chemistry,Asian Journal of Organic Chemistry

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Recent Advances in the Synthesis of Tamoxifen and Analogues in Medicinal Chemistry
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-08-12 , DOI: 10.1002/ajoc.202000308
Nitin Tandon ₁ , Vijay Luxami ₂ , Runjhun Tandon ₁ , Kamaldeep Paul ₂

Affiliation

Abstract: Tamoxifen is one of the important tricyclicethylene moieties and recognized as an important drug candidate because of extensive applications in the field of medicinal and pharmaceutical chemistry. Recently, ample attention is given to this analogue by organic and medicinal chemistry community due to its successful utilization for the inhibition of estrogen receptor in MCF‐7 breast cancer cell lines. Due to its structural character, tamoxifen is also useful in material chemistry. The synthesis of tamoxifen and its anlogues is desirable from easily available chemicals as an important drug candidate. Here, we report a review on various synthetic schemes for tamoxifen and its anlogues employing use of different strategies such as formation of C−C, C=C and C≡C bonds, C−H functionalization, addition to alkynes, insertion reaction, nucleophilic substitution and addition reactions, elimination reaction, reductive couplings etc.

中文翻译：

他莫昔芬的合成及其药物化学类似物的最新进展

摘要：他莫昔芬是重要的三环乙烯部分之一，由于在医药化学领域的广泛应用而被公认为重要的候选药物。最近，有机和药物化学界对该类似物给予了足够的关注，因为该类似物已成功用于抑制MCF-7乳腺癌细胞系中的雌激素受体。由于其结构特征，他莫昔芬在材料化学中也有用。他莫昔芬及其类似物的合成是由容易获得的化学品作为重要的候选药物而期望的。在这里，我们报告了对他莫昔芬及其类似物的各种合成方案的综述，这些方案使用了不同的策略，例如C-C，C = C和C≡C键的形成，CH-H功能化，炔烃的添加，插入反应，

更新日期：2020-10-11

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