Since swine influenza virus was first isolated in 1930, it has become endemic in pigs worldwide. Although large amount of swine influenza vaccines has been used in swine industry, swine influenza still cannot be efficiently controlled and has been an important economic disease for swine industry. The high diversity and varied distribution of different subtypes and genotypes of swine influenza viruses circulating in pigs globally is a major challenge to produce broadly effective vaccines and control disease. Importantly, swine influenza virus is able to cross species barrier to infect humans and even caused influenza pandemic in 2009. Herein, current status and challenge of swine influenza viruses is reviewed and discussed.

自 1930 年首次分离出猪流感病毒以来，该病毒已成为全球猪群中的流行病。尽管猪流感疫苗已在养猪业中大量使用，但猪流感仍无法得到有效控制，已成为养猪业的重要经济疾病。全球猪群中流行的猪流感病毒不同亚型和基因型的高度多样性和不同分布是生产广泛有效的疫苗和控制疾病的重大挑战。重要的是，猪流感病毒能够跨越物种屏障感染人类，甚至在2009年引发了流感大流行。本文对猪流感病毒的现状和挑战进行了回顾和讨论。