C9ORF72 mutations are the most common genetic cause of ALS and FTD, leading to neurodegeneration via complex mechanisms. Mutations also lead to loss of C9ORF72 function and inflammatory diseases in patients and knockout mice. Burberry et al. now show that C9orf72-associated inflammation and premature death in mice are directly modified by the gut microbiome.

中文翻译：

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关于C9ORF72的直觉。

C9ORF72突变是ALS和FTD的最常见遗传原因，可通过复杂机制导致神经变性。突变还导致患者和基因敲除小鼠的C9ORF72功能丧失和炎症性疾病。Burberry等。现在显示，肠道微生物组直接改变了小鼠C9orf72相关的炎症和过早死亡。