Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. From their initial discovery in the 1960s, senescent cells have been hypothesized as potential contributors to the age-associated loss of regenerative potential. Here, we discuss recent evidence that implicates cellular senescence as a central regulatory mechanism of the aging process. We provide a comprehensive overview of age-associated pathologies in which cellular senescence has been implicated. We describe mechanisms by which senescent cells drive aging and diseases, and we discuss updates on exploiting these mechanisms as therapeutic targets. Finally, we critically analyze the use of senotherapeutics and their translation to the clinic, highlighting limitations and suggesting ideas for future applications and developments.

细胞衰老是与大分子改变和促炎细胞因子和分子的分泌有关的稳定的细胞周期停滞状态。从1960年代的最初发现开始，衰老细胞就被认为是与年龄相关的再生潜能丧失的潜在原因。在这里，我们讨论最近的证据，暗示细胞衰老是衰老过程的主要调控机制。我们提供了涉及细胞衰老的与年龄相关的病理的全面概述。我们描述衰老细胞驱动衰老和疾病的机制，并讨论利用这些机制作为治疗靶点的更新。最后，我们批判性地分析了化疗药的使用及其在临床上的翻译，