Abstract The possibility of using fast scanning calorimetry (FSC) to study the kinetics of the solid-state cyclization of dipeptide was demonstrated in the present work for the first time. The activation energy and Arrhenius constant of the cyclization of L-leucyl-L-leucine (Leu-Leu) were estimated. FSC data obtained at heating rates from 18,000 to 54,000 K min−1 were evaluated by non-isothermal kinetics. The dependence of the specific heat capacity cp on temperature was determined for linear and cyclic Leu-Leu dipeptides using differential scanning calorimetry (DSC) and FSC. The application of FSC allows studies of solid-state reactions for expensive substances and compounds synthesized in very small amounts.

中文翻译：

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使用快速扫描量热法研究二肽 L-亮氨酰-L-亮氨酸的固态环化

摘要 目前的工作首次证明了使用快速扫描量热法 (FSC) 研究二肽固态环化动力学的可能性。估计了 L-亮氨酰-L-亮氨酸 (Leu-Leu) 环化的活化能和阿伦尼乌斯常数。通过非等温动力学评估在 18,000 至 54,000 K min-1 的加热速率下获得的 FSC 数据。使用差示扫描量热法 (DSC) 和 FSC 确定了线性和环状 Leu-Leu 二肽的比热容 cp 对温度的依赖性。FSC 的应用允许研究昂贵的物质和非常少量合成的化合物的固态反应。