Abstract Tissue engineering makes use of the principles of medicine, biology and engineering and integrates them into the design of biological substitutes to restore, maintain and improve the functions of tissue. To fabricate a functional tissue, the engineered structures have to be able to mimic the extracellular matrix (ECM), provide the tissue with oxygen and nutrient circulation as well as remove metabolic wastes in the period of tissue regeneration. Continued efforts have been made in order to fabricate advanced functional three-dimensional scaffolds for tissue engineering. Electrospinning has been recognized and served as one of the most useful techniques based on the resemblance between electrospun fibers and the native tissues. Over the past few decades, a bewildering variety of nanofibrous scaffolds have been developed for various biomedical applications, such as tissue regeneration and therapeutic agent delivery. The present review aims to provide with researchers an in-depth understanding of the promising role and the practical region of applicability of electrospinning in tissue engineering and regenerative medicine by highlighting the outcomes of the most recent studies performed in this field. We address the current strategies used for improving the physicochemical interactions between the cells and the nanofibrous surface. We also discuss the progress and challenges associated with the use of electrospinning for tissue engineering and regenerative medicine applications.

中文翻译：

---

用于组织工程应用的静电纺丝

摘要 组织工程利用医学、生物学和工程学原理，将其融入生物替代品的设计中，以恢复、维持和改善组织的功能。为了制造功能性组织，工程结构必须能够模拟细胞外基质 (ECM)，为组织提供氧气和营养循环，并在组织再生期间清除代谢废物。为了制造用于组织工程的先进功能性三维支架，已经做出了持续的努力。基于电纺纤维和天然组织之间的相似性，静电纺丝已被公认为并作为最有用的技术之一。在过去的几十年里，已经为各种生物医学应用开发了令人眼花缭乱的各种纳米纤维支架，例如组织再生和治疗剂递送。本综述旨在通过强调该领域最新研究的成果，让研究人员深入了解静电纺丝在组织工程和再生医学中的有前景的作用和实际适用范围。我们解决了当前用于改善细胞和纳米纤维表面之间物理化学相互作用的策略。我们还讨论了与将静电纺丝用于组织工程和再生医学应用相关的进展和挑战。本综述旨在通过强调该领域最新研究的成果，让研究人员深入了解静电纺丝在组织工程和再生医学中的有前景的作用和实际适用范围。我们解决了当前用于改善细胞和纳米纤维表面之间物理化学相互作用的策略。我们还讨论了与将静电纺丝用于组织工程和再生医学应用相关的进展和挑战。本综述旨在通过强调该领域最新研究的成果，让研究人员深入了解静电纺丝在组织工程和再生医学中的有前景的作用和实际适用范围。我们解决了当前用于改善细胞和纳米纤维表面之间物理化学相互作用的策略。我们还讨论了与将静电纺丝用于组织工程和再生医学应用相关的进展和挑战。我们解决了当前用于改善细胞和纳米纤维表面之间物理化学相互作用的策略。我们还讨论了与将静电纺丝用于组织工程和再生医学应用相关的进展和挑战。我们解决了当前用于改善细胞和纳米纤维表面之间物理化学相互作用的策略。我们还讨论了与将静电纺丝用于组织工程和再生医学应用相关的进展和挑战。