We examined the effects of administration of (E) 4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP) on radiation-induced chromosome damage in mice. Mice were whole-body exposed to γ-rays, 0-4 Gy, and then immediately administered DMAP, 20 mg/kg. After 24 h, mice were sacrificed, femora were removed, marrow was extracted, and chromosome aberrations were scored in the bone marrow cells. With vehicle-only (saline or oil) treatment, radiation dose-dependent damage was seen in aberrant cells, chromosome breaks, chromatid breaks, centric rings, di-, tri-, and tetracentrics, acentric fragments, total aberrations, polyploidy, and pulverization. Post-administration of DMAP was protective as it reduced chromosome damage. DMAP treatment may be a useful protective agent following radiation accidents or radiotherapy.

我们检查了 (E) 4-[4- N , N-二甲基氨基苯基]but-3-en-2-one (DMAP) 对小鼠辐射诱导的染色体损伤的影响。小鼠全身暴露于 γ 射线，0-4 Gy，然后立即给予 DMAP，20 mg/kg。24 h后处死小鼠，取出股骨，提取骨髓，对骨髓细胞进行染色体畸变评分。仅使用载体（盐水或油）处理时，在异常细胞、染色体断裂、染色单体断裂、中心环、二、三和四着丝粒、无着丝粒碎片、总畸变、多倍体和粉化中观察到辐射剂量依赖性损伤. DMAP 给药后具有保护作用，因为它减少了染色体损伤。DMAP 治疗可能是放射事故或放射治疗后有用的保护剂。