Abstract In this work we present a new sensitive electrochemical method for simultaneous determination of ciprofloxacin (antibiotic) and paracetamol (painkiller). For this purpose graphite electrode was modified with titanium dioxide sol as binding agent. TiO2 sol was enriched with gold nanoparticles and CMK-3 type mesoporous carbon, both increasing the composite conductivity, and Nafion, responsible for signal stabilization. Developed sensor has been characterized via cyclic voltammetry technique presenting LOD equal to 0.108 μM and 0.210 μM and sensitivity of 15.93 μA μM−1 and 11.56 μA μM−1 for ciprofloxacin and paracetamol, respectively. For both analytes two linear ranges from 1 to 10 μM and from 10 to 52 μM were found. Developed method enables to determine with high accuracy and precision ciprofloxacin and paracetamol traces in environmental water matrices as well as in certified reference standard of waste water matrix.

中文翻译：

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基于钛溶胶的传感器对环境水中环丙沙星和扑热息痛的电化学传感

摘要 在这项工作中，我们提出了一种新的灵敏电化学方法，可同时测定环丙沙星（抗生素）和扑热息痛（止痛药）。为此，石墨电极用二氧化钛溶胶作为粘合剂进行了改性。TiO2 溶胶富含金纳米粒子和 CMK-3 型介孔碳，两者都增加了复合电导率，而 Nafion 负责信号稳定。开发的传感器已通过循环伏安法技术表征，对环丙沙星和扑热息痛的 LOD 分别为 0.108 μM 和 0.210 μM，灵敏度分别为 15.93 μA μM-1 和 11.56 μA μM-1。发现两种分析物的线性范围为 1 至 10 μM 和 10 至 52 μM。