The aims of this study were to investigate the potential association of arginine vasopressin type 2 receptor (AVPR2) in canine mammary tumours with expression of oestrogen receptors α (ORα) and β (ORβ) and clinicopathological features of the neoplasms. Twenty-six canine mammary tumour samples (11 benign, 15 malignant) were immunolabelled for AVPR2, ORα and ORβ antigens. Moderate to intense immunolabelling of AVPR2 antigen, found in all neoplasms, was not significantly associated with expression of ORα or ORβ antigens or with clinicopathological features. These findings indicate a potential role for AVPR2 in the development of canine mammary tumours and the use of AVPR2-selective vasopressin analogues as therapeutic options.

这项研究的目的是调查犬乳腺肿瘤中2型精氨酸加压素2型受体（AVPR2）与雌激素受体α（ORα）和β（ORβ）的表达以及肿瘤的临床病理特征之间的潜在联系。对26例犬乳腺肿瘤样品（11例良性，15例恶性）进行了AVPR2，ORα和ORβ抗原的免疫标记。在所有肿瘤中发现的AVPR2抗原的中度至强烈免疫标记与ORα或ORβ抗原的表达或临床病理特征无显着相关性。这些发现表明AVPR2在犬乳腺肿瘤的发展中可能具有潜在作用，并且将AVPR2-选择性加压素类似物用作治疗选择。