Studies have indicated that formaldehyde and low temperature are considered to be the factors associated with several respiratory diseases. However, the effect of co-exposure to formaldehyde and low temperature on allergic asthma, and the potential mechanisms, are unknown. In this study, an allergic asthma mouse model was built and mice were exposed to 0.8 mg/m³ formaldehyde and/or subjected to low temperatures of 16 °C. The data showed that exposure to either low temperature or formaldehyde did not induce a significant aggravation on allergic asthma. However, simultaneous exposure to formaldehyde and low temperature was shown to aggravate mucus hypersecretion and inflammation in the lung, lead to an exacerbation of allergic asthma. After blocking the TRPM8 and TRPA1 ion channels, the levels of inflammatory factors reduced. These results demonstrated that co-exposure to formaldehyde and low temperature exacerbate allergic asthma, and that TRPM8 and TRPA1 are involved in this process.

研究表明甲醛和低温被认为是与几种呼吸系统疾病有关的因素。但是，同时暴露于甲醛和低温对过敏性哮喘的影响及其潜在机制尚不清楚。在这项研究中，建立了过敏性哮喘小鼠模型，并将小鼠暴露于0.8 mg / m ³甲醛和/或经受16°C的低温处理。数据表明，暴露于低温或甲醛不会对过敏性哮喘造成明显加重。但是，同时暴露于甲醛和低温下会加剧粘液的过度分泌和肺部炎症，导致过敏性哮喘加重。阻断TRPM8和TRPA1离子通道后，炎症因子水平降低。这些结果表明，同时暴露于甲醛和低温会加剧过敏性哮喘，TRPM8和TRPA1参与了该过程。