Toxocara cati is a cat roundworm and the causative agent of toxocariasis as a cosmopolitan zoonotic disease. As no information has been reported so far, identification of T. cati proteins can be useful for the development of new diagnostic strategies. This study was conducted to identify the major proteins in the adult T. cati tegument using bi-dimensional electrophoresis (2-DE) and shotgun proteomics. A total proteins were identified, among them the metabolic enzymes were the largest group, including: Enolase, triose phosphate isomerase, fructose-bisphosphate aldolase, aldehyde dehydrogenase. The other important protein groups recognized in T. cati, belong to the HSP-family, the structure and motor proteins, such as actin. The role of these proteins have been implicated in parasite–host interactions and modulating cellular immune response, immune regulation in evasion mechanisms of the host immune response. Characterizing T. cati adult proteins play a key role not only in host-parasite interactions, but also in the discovery of drug targets, subunit vaccines against toxocariasis, immunodiagnostic kits for toxocariasis and the identification of novel immuno-modulators that can form the next generation of therapeutic possibilities for inflammatory diseases.

弓形虫是一种猫a虫，是一种弓形虫病的致病因子，是一种世界性人畜共患病。由于迄今尚未报道任何信息，因此鉴定T. cati蛋白可用于开发新的诊断策略。进行这项研究，以使用二维电泳（2-DE）和shot弹枪蛋白质组学来鉴定成年T. cati皮被中的主要蛋白质。总共鉴定出蛋白质，其中代谢酶是最大的组，包括：烯醇酶，磷酸三糖异构酶，果糖-双磷酸醛缩酶，醛脱氢酶。T. cati中识别的其他重要蛋白质组属于HSP家族，其结构和运动蛋白如肌动蛋白。这些蛋白质的作用与寄生虫-宿主相互作用和调节细胞免疫应答，逃避宿主免疫应答机制中的免疫调节有关。表征T. CATI成人蛋白质发挥关键作用，不仅在宿主-寄生虫的相互作用，而且在药物靶标，对弓蛔虫病亚单位疫苗，对弓蛔虫病和新型免疫调节剂的免疫诊断鉴定试剂盒的发现，即可以形成下一代炎性疾病的治疗可能性。