Local tumor therapy through injectable biodegradable hydrogels with controlled drug release has attracted much attention recently, due to their easy operation, low side effect and efficiency. However, most of the reported therapeutic hydrogel system showed a lack of biodegradation tracking and tumor environment-responsive degradation/therapy. Herein, we developed a multifunctional injectable biodegradation-visual citric acid-based self-healing scaffolds with microenvironment-responsive degradation and drug release for safe and efficient skin tumor therapy (FPRC hydrogel). FPRC scaffolds possess multifunctional properties including thermosensitive, injectable, self-healing, photoluminescent and pH-responsive degradation/drug release. The FPRC scaffolds with strong red fluorescence which has good photostability, tissue penetration and biocompatibility can be tracked and monitored to evaluate the degradation of the scaffolds in vivo. Moreover, the FPRC scaffolds showed pH-responsive doxorubicin (DOX) release, efficiently killed the A375 cancer cell in vitro and suppressed the tumor growth in vivo. Compared to the free drug (DOX), the FPRC@DOX scaffolds displayed a significantly high therapeutic effect and less biotoxicity. This work provides an alternative strategy to design smart visual scaffolds for tumor therapy and regenerative medicine.

通过可注射的可生物降解的水凝胶和受控的药物释放进行局部肿瘤治疗，由于其易于操作，副作用低和效率高而引起了人们的广泛关注。然而，大多数报道的治疗性水凝胶系统显示缺乏生物降解追踪和肿瘤环境响应性降解/疗法。在这里，我们开发了一种多功能的可注射生物降解-基于柠檬酸的自修复支架，具有微环境响应性降解和药物释放功能，可用于安全有效的皮肤肿瘤治疗（FPRC水凝胶）。FPRC支架具有多种功能，包括热敏性，可注射性，自我修复，光致发光和pH响应降解/药物释放。FPRC支架具有强烈的红色荧光，具有良好的光稳定性，体内。此外，FPRC支架显示出pH响应性阿霉素（DOX）释放，可在体外有效杀死A375癌细胞并在体内抑制肿瘤生长。与游离药物（DOX）相比，FPRC @ DOX支架显示出显着的高治疗效果和较低的生物毒性。这项工作为设计用于肿瘤治疗和再生医学的智能视觉支架提供了另一种策略。