Proton (¹H) magnetic resonance spectroscopy provides a non-invasive and quantitative measure of brain metabolites. Traumatic brain injury impacts cerebral metabolism and a number of research groups have successfully used this technique as a biomarker of injury and/or outcome in both pediatric and adult TBI populations. However, this technique is underutilized, with studies being performed primarily at centers with access to MR research support. In this paper we present a technical introduction to the acquisition and analysis of in vivo ¹H magnetic resonance spectroscopy and review ¹H magnetic resonance spectroscopy findings in different injury populations. In addition, we propose a basic ¹H magnetic resonance spectroscopy data acquisition scheme (Supplemental Information) that can be added to any imaging protocol, regardless of clinical magnetic resonance platform. We outline a number of considerations for study design as a way of encouraging the use of ¹H magnetic resonance spectroscopy in the study of traumatic brain injury, as well as recommendations to improve data harmonization across groups already using this technique.

质子 ( ¹ H) 磁共振波谱提供了脑代谢物的非侵入性定量测量。创伤性脑损伤会影响脑代谢，许多研究小组已成功使用该技术作为儿童和成人 TBI 人群损伤和/或结果的生物标志物。然而，这项技术并未得到充分利用，研究主要在获得 MR 研究支持的中心进行。在本文中，我们介绍了体内¹ H 磁共振波谱的采集和分析的技术介绍，并回顾了不同损伤人群中¹ H 磁共振波谱的发现。此外，我们提出了一种基本的¹ H 磁共振波谱数据采集方案（补充信息），无论临床磁共振平台如何，都可以将其添加到任何成像协议中。我们概述了研究设计的一些注意事项，作为鼓励在创伤性脑损伤研究中使用¹ H 磁共振波谱的一种方式，以及改善已使用该技术的小组之间数据协调的建议。