Abstract

Mono-, di-, and trimethylation of histone H3K4 in neurons of the mushroom bodies, the structures responsible for learning and memory in insects, were studied in a honeybee. It was shown that, 1 h after training, the number of neurons containing methylated modifications of histone H3—H3K4me1, H3K4me2, and H3K4me3—increases, which is probably associated with transcription activation during this period, while no differences from control were observed 24 h after training. This study contributes to an understanding of the epigenetic mechanisms of memory formation.

中文翻译：

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记忆形成过程中蜜蜂大脑蘑菇体神经元中赖氨酸4对组蛋白H3的甲基化作用

摘要

在蜜蜂中研究了蘑菇体神经元中组蛋白H3K4的单，二和三甲基化，这是负责昆虫学习和记忆的结构。结果表明，训练后1 h，含有组蛋白H3–H3K4me1，H3K4me2和H3K4me3的甲基化修饰的神经元数量增加，这可能与这段时间内的转录激活有关，而与对照组相比，在24 h内没有发现差异训练结束后。这项研究有助于了解记忆形成的表观遗传机制。