Abstract

Nonwoven tubular bioresorbable matrices with an inner diameter of 1.1 mm were obtained by electroforming from solutions of poly (L-lactide) (PLA). Matrices were implanted into the abdominal aorta of rats as a tissue-engineering vascular implant for a period of 2 days to 16 months and showed high biocompatibility, nontoxicity, and pronounced atrombogenic properties. The total implant patency was 93%. Morphometric analysis of the dynamics of population of the matrix with cells showed that, for all observation periods in the outer half of the matrix wall, the number of cells prevails, which indicates the migration of cells from the connective tissue capsule surrounding the matrix. It is shown that two parallel processes occur in the matrix wall: bioresorption of PLA fibers and the formation of connective tissue. Complete bioresorption of matrices with replacement by native tissues, as well as formation of the endothelial and subendothelial layers, took place over the 16 months of the experiment. By this time, all the experimental animals in the reconstruction zone revealed an aneurysmal expansion that did not lead to rupture of the implant. To prevent the development of such complications, it is necessary to develop a method for additional strengthening of the matrix wall.

中文翻译：

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聚（L-丙交酯）用于组织工程血管植入物的小直径可生物吸收的管状基质的形态学研究。

摘要

通过电成型聚（L-丙交酯）（PLA）溶液获得内径为1.1毫米的非织造管状生物可吸收基质。将基质作为组织工程性血管植入物植入大鼠的腹主动脉中，为期2天至16个月，并显示出高的生物相容性，无毒性和明显的致萎缩特性。植入物的总通畅率为93％。对具有细胞的基质的种群动态的形态分析表明，在基质壁外半部分的所有观察期中，细胞数量占优势，这表明细胞从基质周围的结缔组织囊中迁移出来。结果表明，基质壁上发生了两个平行过程：PLA纤维的生物吸收和结缔组织的形成。在实验的16个月中，发生了基质的完全生物吸收并被天然组织置换，以及内皮层和内皮下层的形成。到这个时候，所有在重建区的实验动物都显示出动脉瘤扩张，但并未导致植入物破裂。为了防止这种并发症的发展，有必要开发一种用于进一步加强基质壁的方法。