Abstract

Mammalian hippocampus hosts neural stem cells in the subgranular zone. Here, the neural stem cells are the source of neurogenesis, that happens throughout the lifetime. However, studies show that undifferentiated cells from varied lineage also shape the environment. In the present study, the expression of c-Kit, a marker for hematopoietic stem cells was studied in the mice hippocampal subgranular zone. Immunohistochemistry and reverse transcription-polymerase chain reaction were performed on 12 week-old mice hippocampal tissues. The data shows that c-Kit is present in the mice hippocampus and in the subgranular zone. Therefore, suggesting a possible role of hematopoietic stem cells in the subgranular zone neurogenesis.

中文翻译：

---

c-Kit在小鼠海马亚颗粒区的免疫表达，造血干细胞在亚颗粒区神经发生中的可能作用

摘要

哺乳动物海马体在颗粒下带拥有神经干细胞。在这里，神经干细胞是神经发生的源头，它贯穿一生。但是，研究表明，来自不同谱系的未分化细胞也会影响环境。在本研究中，在小鼠海马亚颗粒区研究了造血干细胞标记c-Kit的表达。在12周龄小鼠海马组织上进行了免疫组织化学和逆转录聚合酶链反应。数据表明，c-Kit存在于小鼠海马和颗粒下区域。因此，提示造血干细胞在颗粒下区神经发生中的可能作用。