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Management of post-traumatic craniovertebral junction dislocation: A PRISMA-compliant systematic review and meta-analysis of casereports.
Neurosurgical Review ( IF 2.5 ) Pub Date : 2020-08-14 , DOI: 10.1007/s10143-020-01366-4
Tomasz Klepinowski 1 , Bartosz Limanówka 1 , Leszek Sagan 1
Affiliation  

Although historically considered fatal, with the advent of improved pre-hospital care, traumatic dislocation of the craniovertebral junction (CVJ) has been increasing in prevalence in neurosurgical centers. As more survivors are reported each year, a timely review with meta-analysis of their management seems necessary. PRISMA checklist was followed step by step. PubMed and Web of Science databases were searched using words “craniovertebral junction dislocation” and their corresponding synonyms. Study eligibility criteria included research studies from 2015 onwards that delineated adult and pediatric patients with confirmed post-traumatic atlantooccipital dislocation (AOD) or atlantoaxial dislocation (AAD) who survived until proper treatment. Of 1475 initial records, 46 articles met eligibility criteria with a total of 141 patients with traumatic CVJ dislocation. Of the patients, 90 were male (63.8%). Mean age of the cohort was 33.3 years (range 1–99 years). Trauma that most often led to this injury was road traffic accident (70.9%) followed by falls (24.6%). The majority of authors support posterior instrumentation of C1-C2 (45.2%) especially by means of Goel-Harms method. At mean follow-up of 15.4 months (range 0.5–60 months), 27.2% of treated patients remained neurologically intact. Of initially symptomatic, 59% improved, 37% were stable, and 4% deteriorated. Instrumenting the occiput in cases of pure AAD was associated with lower chance of neurological improvement in chi-square test (p = 0.0013) as well as in multiple linear regression (β = − 0.3; p = 0.023). The Goel-Harms C1-C2 fusion is currently the most frequently employed treatment. Many survivors remain with no deficits or improve, rarely deteriorate. Involving the occiput in stabilization in cases of AAD without AOD might be related with worse neurological prognosis.



中文翻译:

创伤后颅椎交界处脱位的管理:符合 PRISMA 的系统评价和病例报告的荟萃分析。

尽管历史上被认为是致命的,但随着院前护理的改进,颅椎交界处 (CVJ) 的外伤性脱位在神经外科中心的患病率一直在增加。随着每年报告的幸存者越来越多,似乎有必要对其管理进行及时的荟萃分析。PRISMA 检查表是按步骤进行的。使用“颅椎交界处脱位”及其相应的同义词搜索 PubMed 和 Web of Science 数据库。研究资格标准包括从 2015 年开始的研究,这些研究描述了确诊为创伤后寰枕脱位 (AOD) 或寰枢椎脱位 (AAD) 的成人和儿童患者,这些患者在接受适当治疗后仍存活。在 1475 条初始记录中,46 篇文章符合入选标准,共有 141 名外伤性 CVJ 脱位患者。在患者中,90 名是男性(63.8%)。队列的平均年龄为 33.3 岁(范围 1-99 岁)。最常导致这种伤害的创伤是道路交通事故(70.9%),其次是跌倒(24.6%)。大多数作者支持 C1-C2 (45.2%) 的后路器械,尤其是通过 Goel-Harms 方法。在平均 15.4 个月(范围 0.5-60 个月)的随访中,27.2% 的接受治疗的患者神经功能完好。在最初症状中,59% 改善,37% 稳定,4% 恶化。在纯 AAD 的情况下,对枕骨进行检测与卡方检验中神经系统改善的机会较低有关。最常导致这种伤害的创伤是道路交通事故(70.9%),其次是跌倒(24.6%)。大多数作者支持 C1-C2 (45.2%) 的后路器械,尤其是通过 Goel-Harms 方法。在平均 15.4 个月(范围 0.5-60 个月)的随访中,27.2% 的接受治疗的患者神经功能完好。在最初症状中,59% 改善,37% 稳定,4% 恶化。在纯 AAD 的情况下,对枕骨进行检测与卡方检验中神经系统改善的机会较低有关。最常导致这种伤害的创伤是道路交通事故(70.9%),其次是跌倒(24.6%)。大多数作者支持 C1-C2 (45.2%) 的后路器械,尤其是通过 Goel-Harms 方法。在平均 15.4 个月(范围 0.5-60 个月)的随访中,27.2% 的接受治疗的患者神经功能完好。在最初症状中,59% 改善,37% 稳定,4% 恶化。在纯 AAD 的情况下,对枕骨进行检测与卡方检验中神经系统改善的机会较低有关。2% 的接受治疗的患者神经功能完好。在最初症状中,59% 改善,37% 稳定,4% 恶化。在纯 AAD 的情况下,对枕骨进行检测与卡方检验中神经系统改善的机会较低有关。2% 的接受治疗的患者神经功能完好。在最初症状中,59% 改善,37% 稳定,4% 恶化。在纯 AAD 的情况下,对枕骨进行检测与卡方检验中神经系统改善的机会较低有关。p  = 0.0013) 以及多元线性回归 ( β  = − 0.3; p  = 0.023)。Goel-Harms C1-C2 融合是目前最常用的治疗方法。许多幸存者仍然没有缺陷或改善,很少恶化。在没有 AOD 的 AAD 病例中,让枕骨参与稳定可能与较差的神经预后有关。

更新日期:2020-08-14
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