The aim of this study is to investigate the effect of nano-SiO₂ (NS) particles addition on physico-mechanical properties, microstructure evolution, and apatite-formation ability of bioactive tricalcium silicate (TCS). Furthermore, the concentrations of calcium (Ca), silicon (Si), and phosphorus (P) in phosphate buffer saline solution (PBS) after immersion of TCS-based cements with diverse additions of NS were also evaluated. The results revealed that the setting time of cement pastes lowered significantly from 72 to 51 min with the doping content of NS from 0 to 5%. The compressive strength and Vickers micro-hardness (HV) of cements with addition of 3% NS after setting for 7 days were significantly higher than those of TCS cements without NS. Furthermore, the cements could induce hydroxyapatite (HA) formation on their surfaces in PBS. The storage solution of TCS-based cements was alkaline, and the pH values changed from 12.26 to 12.65. There were no significant differences about Ca, Si, and P concentrations of PBS after immersion of TCS cement with the addition of 3% NS as compared with doping 0% NS. Our results indicated that TCS cement with addition of 3% NS had enhanced physico-mechanical properties and good HA-formation ability and may make it a potential choice for using as a novel dental material.

这项研究的目的是研究纳米SiO _2的作用（NS）颗粒添加对生物活性硅酸三钙（TCS）的物理机械性能，微观结构演变和磷灰石形成能力的影响。此外，还评估了将TCS基水泥与多种NS浸入后，磷酸盐缓冲盐溶液（PBS）中钙（Ca），硅（Si）和磷（P）的浓度。结果表明，水泥浆的凝固时间从72分钟显着降低到51分钟，NS的掺杂含量从0％降低到5％。凝结7天后添加3％NS的水泥的抗压强度和维氏显微硬度（HV）显着高于不含NS的TCS水泥。此外，在PBS中，水泥可诱导其表面形成羟基磷灰石（HA）。TCS基水泥的储存溶液为碱性，pH值从12.26变为12.65。加入3％NS的TCS水泥浸泡后，与添加0％NS相比，PBS中Ca，Si和P的浓度没有显着差异。我们的结果表明，添加3％NS的TCS水泥具有增强的物理机械性能和良好的HA形成能力，可能使其成为新型牙科材料的潜在选择。