The catalytic promiscuity of MML, lipase from Mucor miehei, was reported to catalyze direct aldol reactions between aromatic aldehydes and cyclic ketones in water, ionic liquids, and deep eutectic solvents at 50 °C. Water can promote the catalytic activity of MML. A wide range of aromatic aldehydes reacted with cyclic ketones to provide the corresponding aldol products with high yields (up to 87.2%) and moderate to good diastereoselectivity (up to 3:97 dr).

中文翻译：

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MML在绿色溶剂中催化的直接羟醛反应

据报道，MML的脂肪酶来自Mucor miehei，在50°C时催化水，离子液体和深共熔溶剂中芳香醛和环状酮之间的直接羟醛反应。水可以促进MML的催化活性。各种各样的芳族醛与环状酮反应，以提供相应的醛醇产物，具有高收率（高达87.2％）和中等至良好的非对映选择性（高达3:97 dr）。