3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.,Macromolecular Bioscience

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3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-08-13 , DOI: 10.1002/mabi.202000106
Pelin Erkoc ₁ , Ileyna Uvak ₁ , Muhammad Anwaar Nazeer ₂ , Syeda Rubab Batool ₃ , Yazan Nitham Odeh ₁ , Ozan Akdogan ₁ , Seda Kizilel _{2,

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Affiliation

3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation. Nevertheless, plain natural hydrogels can be easily disintegrated, and their mechanical strengths are usually insufficient for printing process. Hence, composite hydrogels are developed for 3D printing. This study aims to develop a hydrogel ink for extrusion‐based 3D printing which is entirely composed of natural polymers, gelatin, alginate, and cellulose. Physicochemical interactions between the components of the intertwined gelatin‐cellulose‐alginate network are studied via altering copolymer ratios. The structure of the materials and porosity are assessed using infrared spectroscopy, swelling, and degradation experiments. The utility of this approach is examined with two different crosslinking strategies using glutaraldehyde or CaCl₂. Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer–Emmett–Teller surface area analyses. Moreover, cytocompatibility of the hydrogel scaffolds is confirmed on fibroblast cells. The developed material is completely natural, biocompatible, economical, and the method is facile. Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.

中文翻译：

细胞相容性明胶-纤维素-藻酸盐混合水凝胶的 3D 打印。

水凝胶的 3D 生物打印因其制造复杂和定制的支架的潜力而备受关注，这些支架为细胞增殖提供了有利的条件。然而，普通的天然水凝胶很容易分解，并且它们的机械强度通常不足以用于印刷过程。因此，开发了用于 3D 打印的复合水凝胶。本研究旨在开发一种完全由天然聚合物、明胶、藻酸盐和纤维素组成的用于挤压式 3D 打印的水凝胶墨水。通过改变共聚物比例来研究相互缠绕的明胶-纤维素-海藻酸盐网络组分之间的物理化学相互作用。使用红外光谱、溶胀和降解实验评估材料的结构和孔隙率。₂ . 多层圆柱结构已成功 3D 打印，其多孔结构通过扫描电子显微镜和 Brunauer-Emmett-Teller 表面积分析得到证实。此外，水凝胶支架的细胞相容性在成纤维细胞上得到证实。开发的材料完全天然，生物相容性好，经济实惠，方法简便。因此，这项研究对于开发具有生物医学设备和人造组织巨大潜力的先进功能性 3D 水凝胶非常重要。

更新日期：2020-10-12

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