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Epidemiology of COVID‐19: A systematic review and meta‐analysis of clinical characteristics, risk factors, and outcomes
Journal of Medical Virology ( IF 6.8 ) Pub Date : 2020-08-13 , DOI: 10.1002/jmv.26424 Jie Li 1, 2 , Daniel Q Huang 3, 4 , Biyao Zou 5 , Hongli Yang 2 , Wan Zi Hui 4 , Fajuan Rui 1 , Natasha Tang Sook Yee 4 , Chuanli Liu 1 , Sanjna Nilesh Nerurkar 4 , Justin Chua Ying Kai 4 , Margaret Li Peng Teng 3 , Xiaohe Li 6 , Hua Zeng 7 , John A Borghi 8 , Linda Henry 5 , Ramsey Cheung 5, 9 , Mindie H Nguyen 5
Journal of Medical Virology ( IF 6.8 ) Pub Date : 2020-08-13 , DOI: 10.1002/jmv.26424 Jie Li 1, 2 , Daniel Q Huang 3, 4 , Biyao Zou 5 , Hongli Yang 2 , Wan Zi Hui 4 , Fajuan Rui 1 , Natasha Tang Sook Yee 4 , Chuanli Liu 1 , Sanjna Nilesh Nerurkar 4 , Justin Chua Ying Kai 4 , Margaret Li Peng Teng 3 , Xiaohe Li 6 , Hua Zeng 7 , John A Borghi 8 , Linda Henry 5 , Ramsey Cheung 5, 9 , Mindie H Nguyen 5
Affiliation
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Coronavirus disease 2019 (COVID‐19) has become a pandemic, but its reported characteristics and outcomes vary greatly amongst studies. We determined pooled estimates for clinical characteristics and outcomes in COVID‐19 patients including subgroups by disease severity (based on World Health Organization Interim Guidance Report or Infectious Disease Society of America/American Thoracic Society criteria) and by country/region. We searched Pubmed, Embase, Scopus, Cochrane, Chinese Medical Journal, and preprint databases from 1 January 2020 to 6 April 2020. Studies of laboratory‐confirmed COVID‐19 patients with relevant data were included. Two reviewers independently performed study selection and data extraction. From 6007 articles, 212 studies from 11 countries/regions involving 281 461 individuals were analyzed. Overall, mean age was 46.7 years, 51.8% were male, 22.9% had severe disease, and mortality was 5.6%. Underlying immunosuppression, diabetes, and malignancy were most strongly associated with severe COVID‐19 (coefficient = 53.9, 23.4, 23.4, respectively, all P < .0007), while older age, male gender, diabetes, and hypertension were also associated with higher mortality (coefficient = 0.05 per year, 5.1, 8.2, 6.99, respectively; P = .006‐.0002). Gastrointestinal (nausea, vomiting, abdominal pain) and respiratory symptoms (shortness of breath, chest pain) were associated with severe COVID‐19, while pneumonia and end‐organ failure were associated with mortality. COVID‐19 is associated with a severe disease course in about 23% and mortality in about 6% of infected persons. Individuals with comorbidities and clinical features associated with severity should be monitored closely, and preventive efforts should especially target those with diabetes, malignancy, and immunosuppression.
中文翻译：
COVID-19 的流行病学：临床特征、危险因素和结果的系统回顾和荟萃分析
2019 年冠状病毒病 (COVID-19) 已成为一种流行病，但不同研究报告的其特征和结果差异很大。我们确定了 COVID-19 患者临床特征和结果的汇总估计值，包括按疾病严重程度（根据世界卫生组织临时指导报告或美国传染病学会/美国胸科学会标准）和国家/地区划分的亚组。我们检索了2020年1月1日至2020年4月6日期间的Pubmed、Embase、Scopus、Cochrane、中华医学杂志和预印本数据库。纳入了实验室确诊的COVID-19患者的研究及相关数据。两名评审员独立进行研究选择和数据提取。从 6007 篇文章中，分析了来自 11 个国家/地区的 212 项研究，涉及 281 461 人。总体而言，平均年龄为 46.7 岁，51.8% 为男性，22.9% 患有严重疾病，死亡率为 5.6%。潜在的免疫抑制、糖尿病和恶性肿瘤与重症 COVID-19 的相关性最强（系数分别 = 53.9、23.4、23.4，全部P < .0007），而年龄较大、男性、糖尿病和高血压也与严重的 COVID-19 相关。死亡率较高（系数分别为每年 0.05、5.1、8.2、6.99； P = .006‐.0002）。胃肠道（恶心、呕吐、腹痛）和呼吸道症状（气短、胸痛）与严重的 COVID-19 相关，而肺炎和终末器官衰竭与死亡率相关。 COVID-19 与约 23% 的感染者的严重病程和约 6% 的感染者的死亡有关。 应密切监测患有合并症和与严重程度相关的临床特征的个体，预防工作应特别针对患有糖尿病、恶性肿瘤和免疫抑制的患者。
更新日期：2020-08-13
中文翻译：
COVID-19 的流行病学：临床特征、危险因素和结果的系统回顾和荟萃分析
2019 年冠状病毒病 (COVID-19) 已成为一种流行病，但不同研究报告的其特征和结果差异很大。我们确定了 COVID-19 患者临床特征和结果的汇总估计值，包括按疾病严重程度（根据世界卫生组织临时指导报告或美国传染病学会/美国胸科学会标准）和国家/地区划分的亚组。我们检索了2020年1月1日至2020年4月6日期间的Pubmed、Embase、Scopus、Cochrane、中华医学杂志和预印本数据库。纳入了实验室确诊的COVID-19患者的研究及相关数据。两名评审员独立进行研究选择和数据提取。从 6007 篇文章中，分析了来自 11 个国家/地区的 212 项研究，涉及 281 461 人。总体而言，平均年龄为 46.7 岁，51.8% 为男性，22.9% 患有严重疾病，死亡率为 5.6%。潜在的免疫抑制、糖尿病和恶性肿瘤与重症 COVID-19 的相关性最强（系数分别 = 53.9、23.4、23.4，全部P < .0007），而年龄较大、男性、糖尿病和高血压也与严重的 COVID-19 相关。死亡率较高（系数分别为每年 0.05、5.1、8.2、6.99； P = .006‐.0002）。胃肠道（恶心、呕吐、腹痛）和呼吸道症状（气短、胸痛）与严重的 COVID-19 相关，而肺炎和终末器官衰竭与死亡率相关。 COVID-19 与约 23% 的感染者的严重病程和约 6% 的感染者的死亡有关。 应密切监测患有合并症和与严重程度相关的临床特征的个体，预防工作应特别针对患有糖尿病、恶性肿瘤和免疫抑制的患者。
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