Three-dimensional analysis of injury conditions of single muscle fibers in small animals using phase-contrast X-ray imaging.,Microscopy Research and Technique

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Three-dimensional analysis of injury conditions of single muscle fibers in small animals using phase-contrast X-ray imaging.
Microscopy Research and Technique ( IF 2.0 ) Pub Date : 2020-08-13 , DOI: 10.1002/jemt.23561
Jiwon Lee ₁ , Sang-Hun Jang ₂ , Onseok Lee ₃

Affiliation

Muscle damage can reduces the biological functions and lead to ultimately a disease state. For the reason, it is important to accurately check the state of an injury such as atrophy, and it is required to identify the state of fibers constituting the muscle. This study describes a novel method of analyzing single muscle fibers with injury conditions in three‐dimensions. The muscle fibers of the mice were visualized using phase‐contrast X‐ray projection the microstructure. In additions, it was possible to confirm the status by quantitatively analyzing the injury severity of muscle fibers. Significantly, the muscle conditions of multiple individuals were individually determined. This study could contributes to areas where it is very important to identify microdetailed and quantitative changes of state, such as new drug development.

中文翻译：

使用相衬X射线成像对小动物单肌纤维损伤情况的三维分析。

肌肉损伤会降低生物功能并最终导致疾病状态。因此，准确确认萎缩等损伤的状态很重要，需要确定构成肌肉的纤维的状态。本研究描述了一种分析具有三维损伤情况的单根肌肉纤维的新方法。使用相衬 X 射线投影显微结构观察小鼠的肌肉纤维。此外，还可以通过定量分析肌肉纤维的损伤严重程度来确认状态。值得注意的是，多个个体的肌肉状况是单独确定的。这项研究可能有助于确定状态的微观细节和数量变化非常重要的领域，例如新药开发。

更新日期：2020-08-13

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