In cell lineage commitment decisions, a gene regulatory network (GRN) consisting of a limited number of transcription factors forms the regulatory pivot. Myeloid lineage dendritic cells or DCs are specialized cells having the antigen‐presenting ability and are of immense importance in immune surveillance. In this report, we analyze the GRN that governs the lineage commitment of Common DC Progenitor (CDP) cells to conventional dendritic cells (cDC) and plasmacytoid dendritic cells (pDC). We have analyzed the quantitative behavior of the master regulatory circuit of CDP that governs the lineage commitment. Simulations showed that the GRN displays a bi‐stable behavior within a range of parameter values. Several transcription factors, PU.1, IRF8, Flt3, and Stat3, whose concentrations vary significantly in the two steady states, appear to be the key players. We hypothesize that the two stable steady states are precursors of cDC and pDC, and the variation of concentration of these key transcription factors in the two states may be responsible for early events in lineage commitment.

中文翻译：

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常见树突前体细胞主基因调控网络的双稳定性：对细胞分化的影响

在细胞谱系承诺决策中，由数量有限的转录因子组成的基因调控网络 (GRN) 形成了调控枢纽。髓系树突状细胞或 DC 是具有抗原呈递能力的特化细胞，在免疫监视中非常重要。在本报告中，我们分析了控制常见 DC 祖细胞 (CDP) 向常规树突细胞 (cDC) 和浆细胞样树突细胞 (pDC) 的谱系承诺的 GRN。我们已经分析了控制谱系承诺的 CDP 主调节电路的定量行为。模拟表明，GRN 在参数值范围内表现出双稳态行为。几种转录因子，PU.1、IRF8、Flt3 和 Stat3，其浓度在两种稳态下变化显着，似乎是关键球员。我们假设这两种稳定的稳态是 cDC 和 pDC 的前体，并且这两种状态中这些关键转录因子的浓度变化可能是谱系承诺早期事件的原因。