With the rapid global spread of SARS-CoV-2, we have become acutely aware of the inadequacies of our ability to respond to viral epidemics. Although disrupting the viral life cycle is critical for limiting viral spread and disease, it has proven challenging to develop targeted and selective therapeutics. Synthetic lethality offers a promising but largely unexploited strategy against infectious viral disease; as viruses infect cells, they abnormally alter the cell state, unwittingly exposing new vulnerabilities in the infected cell. Therefore, we propose that effective therapies can be developed to selectively target the virally reconfigured host cell networks that accompany altered cellular states to cripple the host cell that has been converted into a virus factory, thus disrupting the viral life cycle.

中文翻译：

---

通过合成致死作用削弱 SARS-CoV-2 和其他病毒的生命支持

随着 SARS-CoV-2 在全球的迅速传播，我们敏锐地意识到我们应对病毒流行病的能力不足。尽管破坏病毒生命周期对于限制病毒传播和疾病至关重要，但事实证明开发靶向和选择性疗法具有挑战性。合成致死性提供了一种很有前途但基本上尚未开发的对抗传染性病毒性疾病的策略；当病毒感染细胞时，它们会异常改变细胞状态，无意中暴露出受感染细胞的新漏洞。因此，我们建议可以开发有效的疗法来选择性地针对伴随细胞状态改变的病毒重新配置的宿主细胞网络，以削弱已转化为病毒工厂的宿主细胞，从而破坏病毒的生命周期。