BACKGROUND Carrion’s disease (CD) is a neglected biphasic illness caused by Bartonella bacilliformis, a Gram-negative bacteria found in the Andean valleys. The spread of resistant strains underlines the need for novel antimicrobials against B. bacilliformis and related bacterial pathogens. OBJECTIVE The main aim of this study was to integrate genomic-scale data to shortlist a set of proteins that could serve as attractive targets for new antimicrobial discovery to combat B. bacilliformis. METHODS We performed a multidimensional genomic scale analysis of potential and relevant targets which includes structural druggability, metabolic analysis and essentiality criteria to select proteins with attractive features for drug discovery. FINDINGS We shortlisted seventeen relevant proteins to develop new drugs against the causative agent of Carrion’s disease. Particularly, the protein products of fabI, folA, aroA, trmFO, uppP and murE genes, meet an important number of desirable features that make them attractive targets for new drug development. This data compendium is freely available as a web server (http://target.sbg.qb.fcen.uba.ar/). MAIN CONCLUSION This work represents an effort to reduce the costs in the first phases of B. bacilliformis drug discovery.

中文翻译：

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通过计算机集成方法对潜在的针对细菌杆菌的潜在靶标进行优先排序。

背景腐肉病（CD）是由细菌性巴尔通体（Bartonella bacilliformis）引起的一种被忽视的双相病，细菌是在安第斯山谷中发现的革兰氏阴性细菌。耐药菌株的传播强调了对新型芽孢杆菌和相关细菌病原体的抗菌剂的需求。目的本研究的主要目的是整合基因组规模的数据，以筛选出一组蛋白质，这些蛋白质可以作为抗击细菌的新抗菌素发现的有吸引力的靶标。方法我们对潜在和相关靶标进行了多维基因组规模分析，包括结构可药用性，代谢分析和必要性标准，以选择具有吸引人特征的蛋白质用于药物发现。研究结果我们筛选了17种相关蛋白，以开发出抗腐肉病病原体的新药。特别是，fabI，folA，aroA，trmFO，uppP和murE基因的蛋白质产物具有许多重要的理想特征，这些特征使它们成为新药开发的有吸引力的靶标。该数据纲要可作为Web服务器免费获得（http://target.sbg.qb.fcen.uba.ar/）。主要结论这项工作代表了降低细菌性芽孢杆菌药物发现第一阶段成本的努力。