Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects.

中文翻译：

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两大奇迹：不断扩大的多目标表观遗传因子。

多靶点涉及故意使用分子以高亲和力结合两个或多个不相关的细胞靶标的分子的应用。在表观遗传化学生物学和药物发现中，多靶点药物的合理设计已发展到复杂的水平，现在有五个实例已进入临床试验。这篇综述涵盖了该领域的最新发展和未来前景。