The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of the extracellular environment, supporting long-range force propagation and the development of low-compliant tissues necessary for the development of vertebrate traits including pressurized circulation and renal filtration. Vertebrates have also evolved integrins that can bind to collagens, resulting in the generation of higher tension and more efficient force transmission in the extracellular matrix. The stiffer environment provides an opportunity for the vertebrates to create new structures such as the stress fibers, new cell types such as endothelial cells, new developmental processes such as neural crest delamination, and new tissue organizations such as the blood-brain barrier. Molecular players found only in vertebrates allow the modification of conserved mechanisms as well as the design of novel strategies that can better serve the physiological needs of the vertebrates. These innovations collectively contribute to novel morphogenetic behaviors and unprecedented increases in the complexities of tissue mechanics and functions.

中文翻译：

---

胶原蛋白、刚度和粘附：脊椎动物力学生物学的进化基础。


脊椎动物中 I 型胶原蛋白的出现导致细胞外环境的硬度急剧增加，支持长程力传播和低顺应性组织的发育，这些组织是脊椎动物特征（包括加压循环和肾过滤）发育所必需的。脊椎动物还进化出了可以与胶原蛋白结合的整合素，从而在细胞外基质中产生更高的张力和更有效的力传递。更僵硬的环境为脊椎动物提供了创造新结构（如应力纤维）、新细胞类型（如内皮细胞）、新发育过程（如神经嵴分层）和新组织组织（如血脑屏障）的机会。仅在脊椎动物中发现的分子参与者可以修改保守机制以及设计新策略，以更好地满足脊椎动物的生理需求。这些创新共同促成了新颖的形态发生行为以及组织力学和功能的复杂性前所未有的增加。