Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. Here, we review the current applications of these epigenetic editing tools in mammals and shed light on biochemical improvements that facilitate versatile applications.

中文翻译：

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表观遗传学编辑的进展。

表观遗传编辑是指表观遗传酶的基因座特异性靶向，以重写内源基因组位点的局部表观遗传景观，通常是为了转录重编程。实施簇状规则间隔的短回文重复序列-dCas9极大地加快了表观遗传编辑的进展，使用多种表观遗传酶在临床前取得了成功的治疗效果。在这里，我们回顾了这些表观遗传编辑工具在哺乳动物中的当前应用，并阐明了促进通用应用的生化改进方法。