OBJECTIVE Currently, there are discrepancies in the reports on the extent of the reduction in platelet count after platelet donation by apheresis, and its impact on mean platelet volume (MPV). This study was conducted to meta-analyze the effect of plateletpheresis on platelet count and on mean platelet volume, based on studies published between 1980 and 2018. METHODS Medline-Pubmed, Scielo, ScienceDirect, and Scopus databases were searched from inception to December 31 2019. The PRISMA guidelines, reproducibility, and evaluation of the methodological quality were guaranteed. Heterogeneity was evaluated with DerSimonian-Laird's, publication bias with a Begg's test. Sensitivity analysis and cumulative meta-analysis were also conducted, as well as a forest plot. RESULTS Twenty-five studies with 3769 donors were systematized to analyze platelet count, and seven studies with 1176 donors to observe MPV. Most studies were published in India and the United States. There was a postprocedure reduction in both variables. The reduction in platelet count was 14.3 × 103 /μL (95% CI 11.4 to 17.1 × 103 ⁄μL). The reduction in MPV was 1.43 fL (95% CI 0.3 to 2.5 fL). The analysis of subgroups showed that, in the case of platelet count, the reduction is not statistically significant two weeks after donation. CONCLUSION Platelet donation by apheresis reduces platelet count and MPV in donors, which is detrimental to the purposes of the procedure; although the decrease is not clinically significant for the donor or the recipient. This demonstrates the need for subsequent studies to evaluate variables, such as donation frequency and donation intervals, should be considered to evaluate if the reported decrease is easily compensated, without adverse consequences for donors, or if modifications in donor selection criteria are required.

中文翻译：

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血小板清除术对总血小板计数和平均血小板体积的影响：荟萃分析。

目的目前，关于通过单采采血捐献血小板后血小板计数减少的程度及其对平均血小板体积（MPV）的影响的报道存在差异。这项研究是根据1980年至2018年发表的研究进行荟萃分析的，以分析血小板减少对血小板计数和平均血小板体积的影响。方法检索从开始到2019年12月31日的Medline-Pubmed，Scielo，ScienceDirect和Scopus数据库。保证了PRISMA指南，可重复性和方法学质量的评估。异质性用DerSimonian-Laird's评估，出版偏倚通过Begg检验。还进行了敏感性分析和累积荟萃分析，以及森林图。结果系统化了25个研究，共3769个供体，分析了血小板计数，进行了7个研究，共1176个供体，观察了MPV。大多数研究在印度和美国发表。两种变量的手术后减少。血小板计数减少14.3×103 /μL（95％CI 11.4至17.1×103 ⁄L）。MPV降低为1.43 fL（95％CI为0.3至2.5 fL）。对亚组的分析表明，就血小板计数而言，捐献后两周的减少没有统计学意义。结论采血的单采血小板减少了供血者的血小板计数和MPV，这不利于手术的目的。尽管这种减少对捐赠者或接受者在临床上并不显着。这表明需要进行后续研究以评估变量，