An understanding of the current change in a solid state nanopore due to particle movement or capture is crucial for improvement of nanopore based sensing technologies. For lower aspect ratio pores, which are gaining importance due to their high sensitivity, there is interplay between access and pore resistance and the existing theories for computation of access resistance cannot explain most of the experimental observations. Hence, there is a need to develop a comprehensive model for calculating the effective conductance drop in presence of particles in a solid state nanopore. In this paper, we develop analytical models to calculate both the access and pore resistance in presence of particle at different positions during translocation and also when captured by receptors in functionalized nanopores. A wide range of pore geometry and molar strength has been investigated. Taking into consideration the positional uncertainty during particle translocation, the effective resistance sensitivity has been found to agree very well with the experimental observations in low aspect ratio pore. Additionally, we observe that in functionalized nanopores, a pore of higher diameter results in around 50% increase in sensitivity compared to a pore with half its diameter, which indicates the scope of design optimization in such systems.

中文翻译：

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模拟固态纳米孔中粒子引起的有效电导下降以实现优化设计


了解由于粒子运动或捕获而导致的固态纳米孔的当前变化对于改进基于纳米孔的传感技术至关重要。对于较低纵横比的孔隙，由于其高灵敏度而变得越来越重要，入口和孔隙阻力之间存在相互作用，并且现有的入口阻力计算理论无法解释大多数实验观察结果。因此，需要开发一种综合模型来计算固态纳米孔中存在颗粒时的有效电导降。在本文中，我们开发了分析模型来计算易位过程中不同位置的颗粒存在以及被功能化纳米孔中的受体捕获时的进入和孔阻。已经研究了各种孔隙几何形状和摩尔强度。考虑到颗粒易位过程中的位置不确定性，发现有效电阻灵敏度与低纵横比孔隙中的实验观察结果非常吻合。此外，我们观察到，在功能化纳米孔中，与直径一半的孔相比，较大直径的孔导致灵敏度提高约 50%，这表明此类系统的设计优化范围。