Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel β-coronavirus, is the main pathogenic agent of the rapidly spreading pneumonia called coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects much more people, especially the elder population, around the world than other coronavirus, such as SARS-CoV and MERS-CoV, which is challenging current global public health system. Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. We summarize the coinfection of virus, bacteria and fungi with SARS-CoV-2, their effects on COVID-19, the reasons of coinfection, and the diagnosis to emphasize the importance of microbial coinfection in COVID-19.

Key points

• Microbial coinfection is a nonnegligible factor in COVID-19.

• Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment.

• Different virus, bacteria, and fungi contributed to the coinfection with SARS-CoV-2.

中文翻译：

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COVID-19 中的微生物双重感染。

 抽象的

严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 是一种新型 β 冠状病毒，是快速传播的肺炎（称为 2019 冠状病毒病 (COVID-19)）的主要病原体。 SARS-CoV-2在全球范围内感染的人群，特别是老年人群，比SARS-CoV和MERS-CoV等其他冠状病毒要多得多，这对当前的全球公共卫生系统构成了挑战。除了 SARS-CoV-2 的发病机制之外，微生物合并感染在 SARS-CoV-2 感染的发生和发展中也发挥着重要作用，增加了 COVID-19 的诊断、治疗和预后的难度，甚至增加了疾病症状和预后。死亡。我们总结了病毒、细菌和真菌与 SARS-CoV-2 的合并感染、它们对 COVID-19 的影响、合并感染的原因以及诊断，以强调微生物合并感染在 COVID-19 中的重要性。

 要点

•微生物合并感染是COVID-19 中不可忽视的因素。

•微生物混合感染加剧了COVID-19的发生、发展和预后进程以及临床诊断和治疗的难度。

•不同的病毒、细菌和真菌导致了SARS-CoV-2 的双重感染。