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Substantial Cellular Penetration of Fluorescent Imidazoquinoxalines.
Journal of Fluorescence ( IF 2.6 ) Pub Date : 2020-08-10 , DOI: 10.1007/s10895-020-02595-y
Cindy Patinote 1 , Natalina Cirnat 1 , Kamel Hadj-Kaddour 1 , Pierre Cuq 1 , Pierre-Antoine Bonnet 1 , Carine Deleuze-Masquéfa 1
Affiliation  

Fluorescent tools have revolutionized our capability to visualize, probe, study, and understand the biological cellular properties, processes and dynamics, enabling researchers to improve their knowledge for example in cancer field. In this paper, we use the peculiar properties of our Imiqualines derivatives to study their cellular penetration and distribution in a human melanoma cell line A375 using confocal microscopy. Preliminary results on colocalization with the potent protein target c-Kit of our lead are also described.



中文翻译:

荧光咪唑并喹喔啉的大量细胞渗透。

荧光工具彻底改变了我们可视化,探测,研究和理解生物细胞特性,过程和动力学的能力,从而使研究人员能够提高自身的知识,例如在癌症领域。在本文中,我们使用共聚焦显微镜研究了咪喹啉衍生物的特殊性质,以研究它们在人黑素瘤细胞系A375中的细胞渗透和分布。还描述了与我们的潜在强力蛋白靶c-Kit共定位的初步结果。

更新日期:2020-08-20
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