Aberrant DNA methylation is a fundamental characterization of epigenetics for carcinogenesis. Abnormality of DNA methylation-related functional elements (DMFEs) may lead to dysfunction of regulatory genes in the progression of cancers, contributing to prognosis of many cancers. There is an urgent need to construct a tool to comprehensively assess the impact of DMFEs on prognosis. Therefore, we developed SurvivalMeth (http://bio-bigdata.hrbmu.edu.cn/survivalmeth) to explore the prognosis-related DMFEs, which documented many kinds of DMFEs, including 309,465 CpG island-related elements, 104,748 transcript-related elements, 77,634 repeat elements, as well as cell-type specific 1,689,653 super enhancers (SE) and 1,304,902 CTCF binding regions for analysis. SurvivalMeth is a convenient tool which collected DNA methylation profiles of 36 cancers and allowed users to query their genes of interest in different datasets for prognosis. Furthermore, SurvivalMeth not only integrated different combinations, including single DMFE, multiple DMFEs, SEs and clinical data, to perform survival analysis on preupload data but also allowed for uploading customized DNA methylation profile of DMFEs from various diseases to analyze. SurvivalMeth provided a comprehensive resource and automated analysis for prognostic DMFEs, including DMFE methylation level, correlation analysis, clinical analysis, differential analysis, DMFE annotation, survival-related detailed result and visualization of survival analysis. In summary, we believe that SurvivalMeth will facilitate prognostic research of DMFEs in diverse cancers.

中文翻译：

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SurvivalMeth：研究 DNA 甲基化相关功能元件对预后影响的网络服务器。

异常的 DNA 甲基化是致癌作用的表观遗传学的基本特征。DNA甲基化相关功能元件（DMFEs）的异常可能导致癌症发展过程中调控基因的功能障碍，从而影响许多癌症的预后。迫切需要构建一种工具来全面评估 DMFE 对预后的影响。因此，我们开发了 SurvivalMeth (http://bio-bigdata.hrbmu.edu.cn/survivalmeth) 来探索与预后相关的 DMFE，其中记录了多种 DMFE，包括 309,465 个 CpG 岛相关元件，104,748 个转录相关元件, 77,634 个重复元件，以及细胞类型特异性的 1,689,653 个超级增强子 (SE) 和 1,304,902 个 CTCF 结合区域用于分析。SurvivalMeth 是一个方便的工具，它收集了 36 种癌症的 DNA 甲基化谱，并允许用户在不同的数据集中查询他们感兴趣的基因以进行预后。此外，SurvivalMeth 不仅集成了不同的组合，包括单个 DMFE、多个 DMFE、SE 和临床数据，对上传前的数据进行生存分析，还允许上传来自各种疾病的 DMFE 的定制 DNA 甲基化谱进行分析。SurvivalMeth 为预后 DMFE 提供了全面的资源和自动化分析，包括 DMFE 甲基化水平、相关性分析、临床分析、差异分析、DMFE 注释、生存相关的详细结果和生存分析的可视化。总之，我们相信 SurvivalMeth 将促进 DMFE 在不同癌症中的预后研究。