Apolipoprotein A‐V encoded by apolipoprotein 5 (APOA5) gene plays an important role in lipid metabolism, especially in the regulation of plasma triglycerol levels. The study aimed to evaluate the association of the APOA5‐rs662799 polymorphism with dyslipidemia in Vietnamese children and the potential modification of obesity‐related traits (body mass index, waist circumference, hip circumference, and waist‐to‐hip ratio) on this association. A case–control study was conducted with a total of 154 dyslipidemia cases and 389 controls at the age of 6 to 10 recruited at 31 primary schools in Hanoi city of Vietnam. Genotype for APOA5‐rs662799 polymorphism was determined by the restriction fragment length polymorphism analysis. The association of APOA5‐rs662799 polymorphism with dyslipidemia adjusting for age, sex, residence, and obesity‐related traits was analyzed by binary logistic regression analysis. The results showed that in comparison with T/T and T/C carriers, the C/C carriers had a higher concentration of serum TAG in cases (p =0.049). Carriers of the C allele (C/C + T/C) had higher risk for developing dyslipidemia and hypertriglyceridemia than subjects with T/T genotype (odds ratio, OR = 1.7, p =0.0062 and OR = 1.6, p = 0.026, respectively). The association remained significant after adjusting for age, gender, residence, and obesity status (OR = 1.75, p = 0.006 and OR = 1.53, p = 0.049, respectively) or other obesity‐related traits. The study suggested that the APOA5‐rs662799 polymorphism may be a determinant of dyslipidemia and hypertriglyceridemia in Vietnamese children, independent of obesity‐related traits.

中文翻译：

---

APOA5-rs662799 多态性是越南小学生血脂异常的决定因素。

由载脂蛋白 5 ( APOA5 ) 基因编码的载脂蛋白 A-V在脂质代谢中起重要作用，尤其是在血浆甘油三酯水平的调节中。该研究旨在评估APOA5- rs662799 多态性与越南儿童血脂异常的关联以及肥胖相关特征（体重指数、腰围、臀围和腰臀比）对这种关联的潜在改变。在越南河内市的 31 所小学共招募了 154 名血脂异常病例和 389 名年龄在 6 至 10 岁之间的对照研究。APOA5 ‐rs662799 多态性的基因型通过限制性片段长度多态性分析确定。APOA5协会通过二元逻辑回归分析调整了年龄、性别、居住地和肥胖相关性状后血脂异常的-rs662799多态性。结果显示，与T/T和T/C携带者相比，C/C携带者在病例中的血清TAG浓度更高（p  =0.049）。C 等位基因 (C/C + T/C) 携带者发生血脂异常和高甘油三酯血症的风险高于具有 T/T 基因型的受试者（优势比，OR = 1.7，p  = 0.0062 和 OR = 1.6，p = 0.026，分别）。在调整年龄、性别、居住地和肥胖状况后，该关联仍然显着（OR = 1.75，p = 0.006 和 OR = 1.53，p= 0.049，分别）或其他与肥胖相关的特征。该研究表明，APOA5- rs662799 多态性可能是越南儿童血脂异常和高甘油三酯血症的决定因素，与肥胖相关的特征无关。