Acoustic-based imaging modalities (e.g. ultrasonography and photoacoustic imaging) have emerged as powerful approaches to noninvasively visualize the interior of the body due to their biocompatibility and the ease of sound transmission in tissue. These technologies have recently been augmented with an array of chemical tools that enable the study and modulation of the tumor microenvironment at the molecular level. In addition, the application of ultrasound and ultrasound-responsive materials has been used for drug delivery with high spatiotemporal control. In this review, we highlight recent advances (in the last 2-3 years) in acoustic-based chemical tools and technologies suitable for furthering our understanding of molecular events in complex tumor microenvironments.

中文翻译：

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用于分析肿瘤微环境的基于声学的化学工具。

基于声学的成像方式（例如超声检查和光声成像）已成为一种强大的方法，可以无创地可视化人体内部，因为它们具有生物相容性并且易于在组织中进行声音传输。最近，通过一系列化学工具增强了这些技术，这些化学工具使得能够在分子水平上研究和调节肿瘤微环境。另外，超声和超声响应材料的应用已经用于具有高时空控制的药物递送。在这篇综述中，我们重点介绍了基于声的化学工具和技术的最新进展（过去2-3年），这些工具和技术适用于加深我们对复杂肿瘤微环境中分子事件的理解。