Cellular senescence has recently become causally implicated in pathological ageing. Hence, a great deal of research is currently dedicated towards developing senolytic agents to selectively kill senescent cells. However, senescence also plays important roles in a range of physiological processes including during organismal development, providing a barrier to tumorigenesis and in limiting fibrosis. Recent evidence also suggests a role for senescence in coordinating tissue remodelling and in the regeneration of complex structures. Through its non-cell-autonomous effects, a transient induction of senescence may create a permissive environment for remodelling or regeneration through promoting local proliferation, cell plasticity, tissue patterning, balancing growth, or indirectly through finely tuned interactions with infiltrating immune mediators. A careful analysis of the beneficial roles of cellular senescence may provide insights into important physiological processes as well as informing strategies to counteract its detrimental consequences in ageing and disease.

中文翻译：

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从灰烬中崛起：再生中的细胞衰老。

最近，细胞衰老与病理性衰老有因果关系。因此，目前有大量研究致力于开发衰老溶解剂以选择性杀死衰老细胞。然而，衰老也在一系列生理过程中发挥重要作用，包括在生物体发育过程中，为肿瘤发生提供屏障和限制纤维化。最近的证据还表明衰老在协调组织重塑和复杂结构再生中的作用。通过其非细胞自主效应，短暂的衰老诱导可以通过促进局部增殖、细胞可塑性、组织模式、平衡生长或间接通过与浸润免疫介质的微调相互作用，为重塑或再生创造一个宽松的环境。