To this day, malaria remains a global burden, affecting millions of people, especially those in sub-Saharan Africa and Asia. The rise of drug resistance to current antimalarial treatments, including artemisinin-based combination therapies, has made discovering new small molecule compounds with novel modes of action an urgent matter. The concerted effort to construct enormous compound libraries and develop high-throughput phenotypic screening assays to find compounds effective at specifically clearing malaria-causing Plasmodium parasites at any stage of the life cycle has provided many antimalarial prospects, but does not indicate their target or mode of action. Here, we review recent advances in antimalarial drug discovery efforts, focusing on the following 'omics' approaches in mode of action studies: IVIEWGA, CETSA, metabolomic profiling.

中文翻译：

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抗疟疾抗药性-寻找新的药物靶标及其作用方式。

时至今日，疟疾仍然是全球性负担，影响着数百万人，尤其是撒哈拉以南非洲和亚洲的人们。对包括基于青蒿素的联合疗法在内的当前抗疟疾治疗方法的耐药性的上升已迫切需要发现具有新作用方式的新小分子化合物。为构建巨大的化合物库并开发高通量表型筛选测定法以寻找在生命周期的任何阶段都能有效特异性清除引起疟疾的疟原虫寄生虫的化合物的共同努力，提供了许多抗疟前景，但并未表明其目标或治疗模式。行动。在这里，我们回顾了抗疟药研发工作的最新进展，重点是作用模式研究中的以下“组学”方法：IVIEWGA，CETSA，代谢组学分析。