Retinal regeneration efficiency from Müller glia varies tremendously among vertebrate species, being extremely limited in mammals. Efforts towards the identification of molecular mechanisms underlying Müller cell proliferative and neurogenic potential should help finding strategies to awake them and ensure regeneration in mammals. We provide here an update on the most recent and original progresses made in the field. These include remarkable discoveries regarding (i) unprecedented cross-species comparison of Müller cell transcriptome using single-cell technologies, (ii) the identification of new strategies to promote both the proliferative and the neurogenic potential of mammalian Müller cells, (iii) the role of the epigenome in regulating Müller glia plasticity, (iv) miRNA-based regulatory mechanisms of Müller cell response to injury, and (v) the influence of inflammatory signals on the regenerative process.

中文翻译：

---

Müller 胶质细胞再生潜力用于视网膜修复的更新。

Müller 神经胶质的视网膜再生效率在脊椎动物物种之间差异很大，在哺乳动物中极为有限。确定 Müller 细胞增殖和神经源性潜能的分子机制的努力应该有助于找到唤醒它们并确保哺乳动物再生的策略。我们在此提供该领域最新和原始进展的最新信息。其中包括以下显着发现：(i) 使用单细胞技术对 Müller 细胞转录组进行前所未有的跨物种比较，(ii) 确定促进哺乳动物 Müller 细胞增殖和神经源性潜力的新策略，(iii)表观基因组在调节 Müller 神经胶质可塑性中的作用，（iv）Müller 细胞损伤反应的基于 miRNA 的调节机制，