Spinal cord injuries disrupt signalling from the brain leading to loss of limb, locomotion, sexual and bladder function, usually irreversible in humans. In zebrafish, recovery of function occurs in a few days for larvae or a few weeks for adults due to regrowth of axons and de novo neurogenesis. Together with its genetic amenability and optical clarity, this makes zebrafish a powerful animal model to study circuit reorganisation after spinal cord injuries. With the fast evolution of techniques, we can forecast significative improvements of our knowledge of the mechanisms leading to successful or failed recovery of spinal cord function. We review here the present knowledge on the subject, the new technological approaches and we propose future directions of research.

中文翻译：

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斑马鱼脊髓损伤后的神经回路重组。

脊髓损伤会破坏来自大脑的信号，导致肢体、运动、性和膀胱功能丧失，这在人类中通常是不可逆转的。在斑马鱼中，由于轴突再生和神经新生，幼虫可在几天内恢复功能，成虫则在几周内恢复功能。加上其遗传适应性和光学清晰度，这使斑马鱼成为研究脊髓损伤后回路重组的强大动物模型。随着技术的快速发展，我们可以预测我们对导致脊髓功能成功或失败恢复的机制的知识的重大改进。我们在这里回顾了关于该主题的现有知识、新技术方法，并提出了未来的研究方向。