Fluorescent biosensors are powerful tools for the detection of biochemical events inside cells with high spatiotemporal resolution. Biosensors based on fluorescent proteins often suffer from issues with photostability and brightness. On the other hand, hybrid, chemical-genetic systems present unique opportunities to combine the strengths of synthetic, organic chemistry with biological macromolecules to generate exquisitely tailored semisynthetic sensors.

中文翻译：

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利用荧光化学-遗传杂交体感应细胞生物化学。

荧光生物传感器是用于以高时空分辨率检测细胞内部生化事件的强大工具。基于荧光蛋白的生物传感器经常遭受光稳定性和亮度问题。另一方面，混合的化学-遗传系统提供了独特的机会，可以将合成的有机化学与生物大分子的优势相结合，以生成精确定制的半合成传感器。